The First Mithridatic War (89–85 BC) was a war challenging Rome's expanding Empire and rule over the Greek world. In this conflict, the Kingdom of Pontus and many Greek cities rebelling against Rome were led by Mithridates VI of Pontus against the Roman RepublicThe Roman Republic was a form of government of Rome and the era of the classical Roman civilization when it was run through public representation of the Roman people. Beginning with the overthrow of the Roman Kingdom (traditionally dated to 509 BC) and ending in 27 BC with the establishment of the Roman Empire, Rome's control rapidly expanded during this period - from the city's immediate surroundings to hegemony over the entire Mediterranean world. and the Kingdom of Bithynia. The war lasted five years and ended in a Roman victory which forced Mithridates to abandon all his conquests and return to Pontus. The conflict with Mithridates VI would continue in two further Mithridatic Wars.
Following his ascension to the throne of Kingdom of Pontus, Mithridates VI of Pontus focused on expanding his kingdom. Mithridates' neighbours, however, were Roman client states, and expansion at their expense would inevitably lead him to conflict with Rome. After successfully incorporating most of the coast around the Black Sea into his kingdom, he turned his attention towards Asia Minor, in particular the Kingdom of Cappadocia, where his sister Laodice was Queen. Mithridates had his brother-in-law, Ariarathes VI, assassinated by Gordius (a Cappadocian nobleman who was allied with Mithridates) leaving the kingdom in the hands of Laodice, who ruled as regent for her son Ariarathes VII of Cappadocia.
Laodice married Nicomedes III of Bithynia, whose country was Pontus' traditional enemy. Nicomedes occupied Cappadocia and Mithridates retaliated by driving him out of Cappadocia and establishing himself as patron of his nephew's kingship on the throne. When Ariarathes refused to welcome Gordius back, Mithridates invaded Cappadocia again and killed Ariarathes. He proceeded to place his son, also called Ariarathes, on the throne of Cappadocia under the guardianship of Gordius.
Nicomedes appealed to the Roman Senate, which decreed that Mithridates be removed from Cappadocia and Nicomedes be removed from Paphlagonia and the Senate appointed Ariobarzanes I of Cappadocia as King of Cappadocia. Mithridates prompted his son-in-law Tigranes the Great of Armenia to invade Cappadocia and remove Ariobarzanes.
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